ProSci

LGR4 /?GPR48 Recombinant Protein

Product Code:
 
PSI-11-136
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-136-0.1mg0.1mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
LGR4, GPR48, G-protein coupled receptor 48, Leucine-rich repeat-containing G-protein coupled receptor 4
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.8 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) together with its family members LGR5 and -6, bind to R-spondins (RSPOs)-1?4 and result in Wnt signaling potentiation. In addition, LGR4 (as well as LGR5 and -6) is implicated in multiple cancers and promotes invasion and metastasis in colorectal, prostate, and cervical cancer cell lines.
Background References:
  • Yue Z. et al. FASEB J. 2018. 32(5):2422-2437.
  • Gao Y. et al. Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 2006 Dec 15; 66(24):11623-31.
  • Gao Y. et al. 2009. Chin. J. Cancer 28, 104?107.
  • Liang F. et al. 2015. Med Oncol. 2015 Mar;32(3):49.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
55366
NCBI Official Name:
leucinerichrepeatcontainingGprotein-coupledreceptor4
NCBI Official Symbol:
LGR4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
58.8 kDa
Protein Accession #:
NP_060960.2
Purity:
>85% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q9BXB1

Documents