ProSci

PLGF / PGF (19-149) Recombinant Protein

Product Code:
 
PSI-11-161
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-161-0.02mg0.02mg£657.00
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Further Information

Additional Names:
PGF,PLGF,PlGF,PGFL,SHGC-10760
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.6 kDa. As a result of glycosylation, the protein migrates as 20-30 kDa under reducing (R) condition, and 45-55 kDa under non-reducing (NR) condition (SDS-PAG
Background:
Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Background References:
  • Maglione D., et al., 1993, Oncogene 8 (4): 925?31.
  • Khalil A., et al., 2008, PLoS ONE 3 (7): e2766.
  • Khurana R., et al., 2005, Circulation 111 (21): 2828?2836.
  • Rolny C., et al., 2011, Cancer Cell 19:31-44.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
5228
NCBI Official Name:
placentalgrowthfactor
NCBI Official Symbol:
PGF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
16.6 kDa
Protein Accession #:
NP_001193941.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P49763

Documents