ProSci

Biotinylated TNFR2 / CD120b / TNFRSF1B Recombinant Protein

Product Code:
 
PSI-11-175
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-175-0.025mg0.025mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
TNFRSF1B,CD120b,TBPII,TNF-R-II,TNF-R75,TNFBR,TNFR1B,TNFR2,TNFR80,p75,p75TNFR
Application Note:
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 28.7 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
TNF RI is also known as the p60 or p55 TNFR) and TNF RII (the p75 or p80 TNFR) are two distinct type I transmembrane glycoproteins that bind TNF with highaffinity.Both RI and RII are prototypic members of the TNF receptor superfamily and have been designated TNFRSF1A and TNFRSF1B, respectively. Human TNF RII cDNA encodes a 461 amino acid (aa) residue precursor protein with a 22 aa putative signal peptide, a 235 aa extracellular domain, a 20 aa transmembrane domain and a 174 aa cytoplasmic domain. TNFRII is expressed in fetal brain. The protein is produced naturally as a soluble form (sTNFRII). The soluble receptor inhibits TNFα action by competing with cell surface receptors in binding TNFα, thereby blocking its biologic effects. TNFRII is strongly expressed at the cartilage?pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). Further, high plasma levels of sTNFRII were significantly associated with increased incidence of coronary heart disease, independent of established cardiovascular risk factors, and seems to be useful for monitoring the inflammatory activity of sarcoidosis.
Background References:
  • Alicia SC, et al., 2005, Molecular and Cellular Biology, 25, No. 11: 4716-26.
  • Ziegenhagen, MW., et al., 2000, Journal of Internal Medicine, 248(1): 33-41.
  • Iris Shai, et al., 2005, Diabetes Care, Vol. 28, No. 6: 1376-1382.
  • MacEwan, D.J., 2002, Cell Signal. 14:477.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag & Avi Tag
NCBI Gene ID #:
7133
NCBI Official Name:
TNFreceptorsuperfamilymember1B
NCBI Official Symbol:
TNFRSF1B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
28.7 kDa
Protein Accession #:
AAA36755
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P20333

Documents