ProSci

VSIG3 Recombinant Protein

Product Code:
 
PSI-11-339
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-339-0.1mg0.1mg£729.00
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Further Information

Additional Names:
VSIG3,IgSF11,CXADRL1,Bt-IgSF,CT119
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway. VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.
Background References:
  • Jang S, et al. 2016. Nat Neurosci.?19:84-93.
  • Watanabe T,?et al.?2005. Cancer Science. 96(8):498-506.
  • Wang J,?et al.?2019. Immunology. 156(1):74-81.
  • Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
152404
NCBI Official Name:
immunoglobulin superfamily member 11
NCBI Official Symbol:
IGSF11
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
49.7 kDa
Protein Accession #:
NP_001015887.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q5DX21

Documents