ProSci

PSMA / FOLH1 Recombinant Protein

Product Code:
 
PSI-11-262
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

No additional charges, what you see is what you pay! *

CodeSizePrice
PSI-11-262-0.1mg0.1mg£838.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Additional Names:
FOLH1,PSMA,GIG27,FOLH,NAALAD1,PSM,NAALADase I,GCPII,FGCP
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 81.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Prostate-specific membrane antigen (PSMA) is also known as Folate hydrolase 1 (FOLH1), Glutamate carboxypeptidase 2 (GCP2), N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1), which belongs to the peptidase M28 family and M28B subfamily. FOLH1 / PSMA is stable at pH greater than 6.5. FOLH1 / PSMA is a type II transmembrane zinc metallopeptidase that is most highly expressed in the nervous system, prostate, kidney, and small intestine. FOLH1 / GCP-2 is homodimer and binds 2 zinc ions per subunit, and required for NAALADase activity. The catalytic activity of PSMA involved in releasing of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly ? gamma - glutamates. FOLH1 / GCP-2 / PSMA has both folate hydrolase and N ? acetylated ? alpha ? linked - acidic dipeptidase (NAALADase) activity and has a preference for tri-alpha-glutamate peptides. GCP-2 / PSMA involved in prostate tumor progression and also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Background References:
  • Grauer L.S., et al., 1998, Cancer Res. 58:4787-4789.
  • Mesters J.R., et al., 2006, EMBO J. 25:1375-1384.
  • Barinka C., et al., 2009, J. Med. Chem. 50:3267-3273.
Buffer:
MES?and?NaCl
Fusion Tag:
His Tag
NCBI Gene ID #:
53320
NCBI Official Name:
folate hydrolase 1
NCBI Official Symbol:
Folh1
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
81.5 kDa
Protein Accession #:
NP_058050.3
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O35409

Documents