ProSci

HMGB1 Recombinant Protein

Product Code:
 
PSI-11-352
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-352-0.1mg0.1mg£838.00
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Further Information

Additional Names:
HMGB1,HMG1,HMG3,SBP-1
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.8 kDa. The protein migrates as 33 kDa and 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
Background References:
  • Wang H, et al., 1999, Science 285 (5425): 248?51.
  • Yang H, et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107 (26): 11942?7.
  • Yang H, et al., 2010, Biochim. Biophys. Acta 1799 (1-2): 149?56.
  • Fagone P, et al., 2011, Gene Ther. 18 (11): 1070?7.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
15289
NCBI Official Name:
high mobility group box 1
NCBI Official Symbol:
Hmgb1
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
26.8 kDa
Protein Accession #:
NP_034569.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P63158

Documents