ProSci

CD27 Ligand / CD70 Recombinant Protein

Product Code:
 
PSI-11-494
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-494-0.1mg0.1mg£657.00
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This product comes from: United States.
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Further Information

Additional Names:
CD70,CD27LG,TNFSF7,TNFSF7G,CD27L
Application Note:
This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 43.5 kDa. The protein migrates as 47-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
Background References:
  • McEarchern JA. et al., 2008, Clin Cancer Res., 14(23):7763-72.
  • Croft M., 2003, Nat Rev Immunol., 3(8):609-20.
  • Kobata, TS. et al., 1995, Proc. Natl. Acad. Sci. USA, 92: 11249?11253.
  • Raman V.S. et al., 2003, J Immunol., 171(11):5876-81.
Buffer:
50 mM Tris, 100 mM Glycine, pH7.5
Fusion Tag:
Mouse IgG Fc Tag
NCBI Gene ID #:
21948
NCBI Official Name:
CD70 antigen
NCBI Official Symbol:
Cd70
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
43.5 kDa
Protein Accession #:
NP_035747.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
O55237

Documents