ProSci

IL-6 Recombinant Protein

Product Code:
 
PSI-11-126
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-126-0.05mg0.05mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
IL6,Interleukin-6,BSF2,HSF,IFNB2
Application Note:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 23.6 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Interleukin 6 (IL-6) is also known as HGF, BSF2,HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts,endothelial cells,et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes,atherosclerosis, depression,Alzheimer's Disease,systemic,lupus erythematosus,prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.
Background References:
  • Ferguson-Smith AC,et.al. 1988, Genomics 2 (3): 203?8.
  • Schwantner A,et. al. 2004, J. Biol. Chem. 279 (1): 571?6.
  • Schuster B,et. al. 2003, J. Biol. Chem. 278 (11): 9528?35.
  • Taga T,et al.1989, Cell 58 (3): 573?81.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
16193
NCBI Official Name:
interleukin6
NCBI Official Symbol:
Il6
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
23.6 kDa
Protein Accession #:
NP_112445.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P08505

Documents