ProSci

Mesothelin / MSLN (298-600) Recombinant Protein

Product Code:
 
PSI-11-217
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-217-0.1mg0.1mg£729.00
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This product comes from: United States.
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Further Information

Additional Names:
MSLN,Mesothelin,MPF
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.0 kDa. The protein migrates as 42-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Background References:
  • Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140.
  • Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808.
  • Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198.
  • Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
56047
NCBI Official Name:
mesothelin
NCBI Official Symbol:
Msln
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
36.0 kDa
Protein Accession #:
NP_061345.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q61468

Documents