ProSci

Rhesus macaque Growth Hormone R (GHR) Recombinant Protein

Product Code:
 
PSI-11-379
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Rhesus Macaque
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-379-0.1mg0.1mg£729.00
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Further Information

Additional Names:
GHR,GHBP,GH receptor
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.7 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Background References:
  • Duquesnoy P., et al., 1994, EMBO J. 13:1386-1395.
  • Urbanek M., et al., 1993, J. Biol. Chem. 268:19025-19032.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
Fc Tag
NCBI Gene ID #:
697986
NCBI Official Name:
growth hormone receptor
NCBI Official Symbol:
GHR
NCBI Organism:
Macaca mulatta
Physical State:
Lyophilized
Predicted Molecular Weight:
54.7 kDa
Protein Accession #:
NP_001036132.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
P79194

Documents