Antibody Isotype:
Mouse IgG1, k
Antibody Clonality:
Monoclonal
Antibody Clone:
1364CT291.108.155
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Aliquot the AURKA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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This product comes from:
United States.
Typical lead time:
10-14 working days.
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Further Information
IHC (Paraffin): 1:25,Western blot: 1:1000
Titration of the AURKA antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
Purified
In 1X PBS, pH 7.4, with 0.09% sodium azide
This AURKA antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from the human region of human AURKA.
This AURKA antibody is available for research use only.
Purified
Human
O14965