NSJ Bioreagents

FZR1 Antibody / Fizzy related protein 1

Product Code:
 
NSJ-F53804
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1621CT637.76.67
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the FZR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of human 1) 293T/17 and 2) HeLa cell lysate with FZR antibody at 1:2000. Predicted molecular weight: 55 kDa.
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Western blot testing of human 1) 293T/17 and 2) HeLa cell lysate with FZR antibody at 1:2000. Predicted molecular weight: 55 kDa.

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CodeSizePrice
NSJ-F53804-0.05ML0.05 ml£260.00
Quantity:
NSJ-F53804-0.2ML0.2 ml£502.00
Quantity:
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Further Information

Application Details :
Western blot: 1:1000-2000
Description:
Fizzy related protein 1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Format :
Purified
Formulation :
In 1X PBS, pH 7.4, with 0.09% sodium azide
Gene ID #:
51343
Immunogen:
Human recombinant protein corresponding to amino acids 1-496 was used as the immunogen for this FZR1 antibody.
Limitation:
This FZR1 antibody is available for research use only.
Purity:
Protein G affinity chromatography
Species Reactivity :
Human
Uniprot #:
Q9UM11