NSJ Bioreagents

SERPINB3 Antibody / SCCA-1

Product Code:
 
NSJ-V7494
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
CPTC-SERPINB3-2
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store the SERPINB3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using SERPINB3 antibody. These results demonstrate the foremost specificity of the CPTC-SERPINB3-2 mAb.<BR>Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluoresc

Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using SERPINB3 antibody. These results demonstrate the foremost specificity of the CPTC-SERPINB3-2 mAb.<BR>Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluoresc

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NSJ-V7494-20UG20 ug£264.00
Quantity:
NSJ-V7494-100UG100 ug£534.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details :
Western blot: 0.5-1ug/ml
Application Note:
Optimal dilution of the SERPINB3 antibody should be determined by the researcher.
Description:
Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of 'squamous cell carcinoma antigen', known as SCCA1 and SERPINB3, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1/SERPINB3 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Immunogen:
Recombinant human protein was used as the immunogen for this SERPINB3 antibody.
Limitation:
This SERPINB3 antibody is available for research use only.
Localization:
Cytoplasmic
Microarray Validated?:
Yes
Purity:
Protein G affinity chromatography
Species Reactivity :
Human
Uniprot #:
P29508