South Bay Bio

Mpro [3CLpro] (SARS-CoV-2) (rec.) (His)

Product Code:
 
SBB-DE0129
Product Group:
 
Recombinant Proteins
Supplier:
 
South Bay Bio
Host Type:
 
E.coli
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
DRY ICE
Storage:
 
Short Term Storage: -80?C. Long Term Storage: -80?C
 

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SBB-DE0129-C05050 ug£315.00
Quantity:
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This product comes from: Switzerland.
Typical lead time: 10-14 working days.
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Further Information

Alternate Names/Synonyms:
Chymotrypsin Like Protease; SARS Coronavirus Main Proteinase
Concentration:
Lot dependent.
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 1mM TCEP.
Handling Advice:
Aliquot to avoid freeze/thaw cycles.
Long Description:
Recombinant Protein. Mpro (Papain-like Protease) (aa 1540-1841) is fused at the N-terminus to a His-tag.. Source: E. coli. Liquid. In 50mM HEPES pH 7.5, 100mM NaCl, 1mM TCEP. 3CLpro recognizes the peptide sequence LQ[S/A/G] where it cleaves c-terminal to the amino acid glutamine (use product SBB-PS0130, KTSAVLQ-Rh110-Glu as universal substrate). The protease 3CLpro is a potential drug target for coronavirus infections due to its essential role in processing the polyproteins that are translated from the viral RNA. The X-ray structures of the unliganded SARS-CoV-2 protease 3CLpro and its complex with an alpha-ketoamide inhibitor provides a basis for design of alpha-ketoamide inhibitors. This SARS Coronavirus recombinant 3CLpro is N-terminally His10-tagged and expressed in E.coli.
Molecular Weight:
~36kDa
NCBI, Uniprot Number:
P0C6U8
Package Type:
Plastic Vial
Product Description:
3CLpro recognizes the peptide sequence LQ[S/A/G] where it cleaves c-terminal to the amino acid glutamine (use product SBB-PS0130, KTSAVLQ-Rh110-Glu as universal substrate). The protease 3CLpro is a potential drug target for coronavirus infections due to its essential role in processing the polyproteins that are translated from the viral RNA. The X-ray structures of the unliganded SARS-CoV-2 protease 3CLpro and its complex with an alpha-ketoamide inhibitor provides a basis for design of alpha-ketoamide inhibitors. This SARS Coronavirus recombinant 3CLpro is N-terminally His10-tagged and expressed in E.coli.
Purity:
>98% (SDS-PAGE)
Sequence:
Mpro (Papain-like Protease) (aa 1540-1841) is fused at the N-terminus to a His-tag.
Source / Host:
E. coli
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C.