IGFL3 (human) (rec.)

Insulin Growth Factor-like Family Member 3

0.1mg/ml after reconstitution

32160000

<0.5EU/?g purified protein (LAL test; Lonza).

solid

Lyophilized. Contains PBS.

After reconstitution, prepare aliquots and store at -20?C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.

Protein. Human IGFL3 (aa 25-125) is fused at the N-terminus to a FLAG?-tag. Source: HEK 293 cells. Endotoxin content: <0.5EU/?g purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human IGFLR1 (Prod. No. AG-40B-0087 http://www.adipogen.com/ag-40b-0087/igflr1-human-fc-human-rec.html ). Purity: >95% (SDS-PAGE). Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

~15-17kDa (SDS-PAGE); ~100kDa (Hexamer) by SEC

Q6UXB1

Plastic Vial

Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

>95% (SDS-PAGE)

Human IGFL3 (aa 25-125) is fused at the N-terminus to a FLAG?-tag.

HEK 293 cells

Binds to human IGFLR1 (Prod. No. AG-40B-0087 http://www.adipogen.com/ag-40b-0087/igflr1-human-fc-human-rec.html ).

FLAG

Non-hazardous

Other Proteins

12352202

Stable for at least 6 months after receipt when stored at -20?C. Working aliquots are stable for up to 3 months when stored at -20?C.