ProSci

Ansuvimab Antibody, Monoclonal

Product Code:
 
PSI-21-872
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Recombinant Antibody
Regulatory Status:
 
RUO
Storage:
 
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4?C short term (1-2 weeks). Store at -20 ?C 12 months. Store at -80?C long term.
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PSI-21-872-0.1mg0.1mg£657.00
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Further Information

Background:
Responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into dendritic cells (DCs) and endothelial cells . Binding to the macrophage specific lectin CLEC10A also seem to enhance virus infectivity. Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. Members of the Tyro3 receptor tyrosine kinase family also seem to be cell entry factors in filovirus infection. Once attached, the virions are internalized through clathrin-dependent endocytosis and/or macropinocytosis. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L presumably induces a conformational change of GP2, allowing its binding to the host entry receptor NPC1 and unmasking its fusion peptide to initiate membranes fusion.
Buffer:
PBS buffer pH 7.5
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Humanized / GP1 surface protein of Ebolavirus
NCBI Gene ID #:
911829
NCBI Official Name:
second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein
NCBI Official Symbol:
GP
NCBI Organism:
Zaire ebolavirus
Protein Accession #:
Q05320
Purification:
>95%
Purity:
>95%
Research Area:
Drug Analogues
Source:
XtenCHO
Swissprot #:
Q05320
User NOte:
For research use only .