ProSci

Anti CD146/MUC18 (c3.19.1) Antibody, Monoclonal

Product Code:
 
PSI-21-877
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
Human IgG2
Antibody Clonality:
 
Recombinant Antibody
Regulatory Status:
 
RUO
Storage:
 
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4?C short term (1-2 weeks). Store at -20 ?C 12 months. Store at -80?C long term.
 

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CodeSizePrice
PSI-21-877-0.1mg0.1mg£657.00
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Further Information

Additional Names:
c3.19.1, CD146; MUC18; HEMCAM; METCAM; MelCAM
Background:
c3.19.1refers to a fully human IgG2 monoclonal antibody directed against the MUC18 antigen. The antibody was generated using XenoMouse? technology (Abgenix, Inc. Fremont, Calif.) and consists of human gamma 2 heavy and kappa light chains with a molecular weight of approximately 150 kDa. CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
Buffer:
PBS buffer pH 7.5
Concentration:
batch dependent
Conjugate:
Unconjugated
Immunogen:
Humanized / CD146/MUC18 [Homo sapiens]
NCBI Gene ID #:
4162
NCBI Official Name:
melanoma cell adhesion molecule
NCBI Official Symbol:
MCAM
NCBI Organism:
Homo sapiens
Protein Accession #:
P43121
Purification:
>95%
Purity:
>95%
Research Area:
Drug Analogues
Source:
XtenCHO
Swissprot #:
P43121
User NOte:
For research use only .