TargetMol

PIN1 inhibitor API-1

Product Code:
 
TAR-T16538
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16538-1mg1mg£115.00
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TAR-T16538-5mg5mg£174.00
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TAR-T16538-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T16538-10mg10mg£269.00
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TAR-T16538-25mg25mg£362.00
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TAR-T16538-50mg50mg£503.00
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TAR-T16538-100mg100mg£616.00
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TAR-T16538-200mg200mg£830.00
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  • Further Information
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Further Information

Bioactivity:
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
CAS:
680622-70-2
Formula:
C15H13F3N6O2
Molecular Weight:
366.304
Purity:
0.9848
SMILES:
Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2[nH]cnc2n1

Documents

References

1. Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.