TargetMol

SB-265610

Product Code:
 
TAR-T16850
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16850-1mg1mg£111.00
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TAR-T16850-5mg5mg£168.00
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TAR-T16850-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T16850-10mg10mg£229.00
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TAR-T16850-25mg25mg£389.00
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TAR-T16850-50mg50mg£544.00
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TAR-T16850-100mg100mg£748.00
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TAR-T16850-500mg500mg£1,460.00
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Further Information

Bioactivity:
SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).
CAS:
211096-49-0
Formula:
C14H9BrN6O
Molecular Weight:
357.171
Pathway:
GPCR/G Protein; Autophagy; Immunology/Inflammation
Purity:
0.9767
SMILES:
Brc1ccccc1NC(=O)Nc1ccc(C#N)c2nn[nH]c12
Target:
CXCR

References

1. Auten RL, et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5. 2. Milatovic S, et al. Impaired healing of nitrogen mustard wounds in CXCR2 null mice. Wound Repair Regen. 2003 May-Jun;11(3):213-9. 3. Li Yang, et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell. 2008 Jan;13(1):23-35.