TargetMol

YKL-5-124

Product Code:
 
TAR-T22461
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22461-1mg1mg£148.00
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TAR-T22461-2mg2mg£181.00
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TAR-T22461-5mg5mg£230.00
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TAR-T22461-1mL1 mL * 10 mM (in DMSO)£261.00
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TAR-T22461-10mg10mg£359.00
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TAR-T22461-25mg25mg£534.00
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TAR-T22461-50mg50mg£732.00
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Quantity:
TAR-T22461-100mg100mg£946.00
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Further Information

Bioactivity:
YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13.
CAS:
1957203-01-8
Formula:
C28H33N7O3
Molecular Weight:
515.618
Pathway:
Cell Cycle/Checkpoint
Purity:
0.995
SMILES:
CN(C)C[C@@H](NC(=O)N1Cc2c(NC(=O)c3ccc(NC(=O)C=C)cc3)n[nH]c2C1(C)C)c1ccccc1
Target:
CDK

References

1. Olson CM, Liang Y, Leggett A, Park WD, Li L, Mills CE, Elsarrag SZ, Ficarro SB, Zhang T, D?ster R, Geyer M, Sim T, Marto JA, Sorger PK, Westover KD, Lin CY, Kwiatkowski N, Gray NS. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10.