TargetMol

PD-161570

Product Code:
 
TAR-T23127
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T23127-1mg1mg£149.00
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TAR-T23127-2mg2mg£181.00
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TAR-T23127-5mg5mg£249.00
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TAR-T23127-1mL1 mL * 10 mM (in DMSO)£278.00
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TAR-T23127-10mg10mg£334.00
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TAR-T23127-25mg25mg£515.00
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Quantity:
TAR-T23127-50mg50mg£704.00
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TAR-T23127-100mg100mg£930.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively.
CAS:
192705-80-9
Formula:
C26H35Cl2N7O
Molecular Weight:
532.51
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9923
SMILES:
CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl
Target:
EGFR; FGFR; PDGFR; Src

Documents

References

1. Hamby JM, et al. Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. J Med Chem. 1997 Jul 18;40(15):2296-303.