TargetMol

Piclamilast

Product Code:
 
TAR-T23154
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T23154-1mg1mg£111.00
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TAR-T23154-2mg2mg£130.00
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TAR-T23154-5mg5mg£168.00
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TAR-T23154-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T23154-10mg10mg£229.00
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TAR-T23154-25mg25mg£414.00
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TAR-T23154-50mg50mg£584.00
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TAR-T23154-100mg100mg£785.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
Piclamilast is a PDE4 inhibitor.
CAS:
144035-83-6
Formula:
C18H18Cl2N2O3
Molecular Weight:
381.25
Pathway:
Metabolism
Purity:
0.98
SMILES:
COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Target:
PDE

Documents

References

1. Manuel Mata, et al. Piclamilast inhibits the pro-apoptotic and anti-proliferative responses of A549 cells exposed to H(2)O(2) via mechanisms involving AP-1 activation. Free Radic Res. 2012 May;46(5):690-9. 2. Edoardo Parrella, et al. Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways. J Biol Chem . 2004 Oct 1;279(40):42026-40. 3. M J Ashton, et al. Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues. J Med Chem. 1994 May 27;37(11):1696-703. 4. T Ukita, et al. Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives. J Med Chem. 1999 Mar 25;42(6):1088-99.