TargetMol

2-Oleoylglycerol

Product Code:
 
TAR-T37526
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T37526-1mg1mg£203.00
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TAR-T37526-5mg5mg£453.00
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TAR-T37526-10mg10mg£528.00
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TAR-T37526-25mg25mg£970.00
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Further Information

Bioactivity:
2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol , is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases.[1][2][3] 2-OG is an agonist of GPR119 (EC50 = 2.5 µM), stimulating the release of glucagon-like peptide-1 from intestinal L-cells. [4]
CAS:
3443-84-3
Formula:
C21H40O4
Molecular Weight:
356.547
Purity:
0.98
SMILES:
CCCCCCCCC=C/CCCCCCCC(=O)OC(CO)CO

References

Ghafouri, N., Tiger, G., Razdan, R.K., et al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. British Journal of Pharmacology 143, 774-784 (2004). Woodhams, S.G., Wong, A., Barrett, D.A., et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. Brit.J.Pharmacol. 167, 1609-1619 (2012). Hansen, K.B., Rosenkilde, M.M., Knop, F.K., et al. 2-Oleoyl glycerol is a GRP119 agonist and signals GLP-1 release in humans. Journal of Clinical Endocrinology and Metabolism 96(9), E1409-E1417 (2011). Brengdahl, J., and Fowler, C.J. A novel assay for monoacylglycerol hydrolysis suitable for high-throughput screening. Analytical Biochemistry 359, 40-44 (2006).