TargetMol

ARD-2128

Product Code:
 
TAR-T39695
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39695-1mg1mg£254.00
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Quantity:
TAR-T39695-2mg2mg£345.00
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TAR-T39695-5mg5mg£535.00
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TAR-T39695-10mg10mg£740.00
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TAR-T39695-25mg25mg£1,091.00
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Quantity:
TAR-T39695-50mg50mg£1,428.00
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Quantity:
TAR-T39695-100mg100mg£1,910.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
ARD-2128 is a highly potent, orally bioavailable PROTAC degrader of androgen receptor (AR). ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer.
CAS:
2222111-87-5
Formula:
C45H50ClN7O6
Molecular Weight:
820.38
Pathway:
Endocrinology/Hormones
Purity:
0.98
SMILES:
CC(C)([C@H](C1(C)C)NC(c(cc2)ccc2N2CCN(CC(CC3)CCN3c(cc3)cc(C(N4C(CCC(N5)=O)C5=O)=O)c3C4=O)CC2)=O)[C@H]1Oc(cc1)cc(Cl)c1C#N
Target:
Androgen Receptor

References

Han X, et al. Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer [published online ahead of print, 2021 Aug 25]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00882.