TargetMol

ASP2453

Product Code:
 
TAR-T39738
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T39738-1mg1mg£165.00
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TAR-T39738-5mg5mg£309.00
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TAR-T39738-10mg10mg£430.00
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TAR-T39738-1mL1 mL * 10 mM (in DMSO)£438.00
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TAR-T39738-25mg25mg£630.00
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TAR-T39738-50mg50mg£822.00
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This product comes from: United States.
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Further Information

Bioactivity:
ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
CAS:
2241719-73-1
Formula:
C40H48F3N7O4
Molecular Weight:
747.85
Pathway:
GPCR/G Protein; MAPK
Purity:
0.98
SMILES:
Cc(ccc1c2cn[nH]1)c2-c(c(C1CC1)cc(c1n2)c(N3CCC(C4)(CN4C(C=C)=O)CC3)nc2OC2CCN(CCCOC)CC2)c1OCC(F)(F)F
Target:
Ras

Documents

References

Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.