TargetMol

CDK12-IN-2

Product Code:
 
TAR-T39752
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39752-1mg1mg£164.00
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Quantity:
TAR-T39752-2mg2mg£206.00
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TAR-T39752-5mg5mg£303.00
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Quantity:
TAR-T39752-1mL1 mL * 10 mM (in DMSO)£326.00
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TAR-T39752-10mg10mg£470.00
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Quantity:
TAR-T39752-25mg25mg£707.00
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Quantity:
TAR-T39752-50mg50mg£978.00
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Quantity:
TAR-T39752-100mg100mg£1,291.00
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Quantity:
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Further Information

Bioactivity:
CDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
CAS:
2244987-03-7
Formula:
C32H32N6O2
Molecular Weight:
532.64
Pathway:
Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
N(C(NCC1=CC=CC=C1)=O)(C2=CC=C(C=C2)C3=CN(C)C(=O)C=C3)[C@H]4CC[C@H](NC5=CC=C(C#N)C=N5)CC4
Target:
CDK

References

Masahiro Ito, et al. Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors. J Med Chem. 2018 Sep 13;61(17):7710-7728.