TargetMol

CHMFL-BMX-078

Product Code:
 
TAR-T4268
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4268-1mg1mg£135.00
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TAR-T4268-5mg5mg£229.00
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TAR-T4268-1mL1 mL * 10 mM (in DMSO)£289.00
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TAR-T4268-10mg10mg£322.00
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TAR-T4268-25mg25mg£544.00
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TAR-T4268-50mg50mg£755.00
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Quantity:
TAR-T4268-100mg100mg£1,010.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.
CAS:
1808288-51-8
Formula:
C33H35N7O6
Molecular Weight:
625.686
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.98
SMILES:
CNc1nc(Nc2ccc(C)c(NC(=O)C=C)c2)ncc1C(=O)Nc1cc(NC(=O)c2cc(OC)c(OC)c(OC)c2)ccc1C
Target:
BTK

Documents

References

Liang X, et al. Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. J Med Chem. 2017 Mar 9;60(5):1793-1816.