TargetMol

BC-1471

Product Code:
 
TAR-T8706
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8706-1mg1mg£123.00
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TAR-T8706-5mg5mg£201.00
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TAR-T8706-1mL1 mL * 10 mM (in DMSO)£242.00
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TAR-T8706-10mg10mg£282.00
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TAR-T8706-25mg25mg£523.00
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TAR-T8706-50mg50mg£723.00
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Quantity:
TAR-T8706-100mg100mg£978.00
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This product comes from: United States.
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Further Information

Bioactivity:
BC-1471 is a novel selective antagonist of deubiquitinase STAM-binding protein (STAMBP), decreasing NALP7 protein levels and suppressing IL-1β release after TLR agonism.
CAS:
896683-78-6
Formula:
C27H28N4O4S
Molecular Weight:
504.61
Purity:
0.998
SMILES:
O=C(CSc1nc2ccc(cc2c(=O)n1CCc1ccccc1)N1CCOCC1)NCc1ccco1

References

Guo Y, Liu Q, Mallette E, et al. Structural and functional characterization of ubiquitin variant inhibitors for the JAMM-family deubiquitinases STAMBP and STAMBPL1. Journal of Biological Chemistry. 2021: 101107. Joseph S Bednash, Nathaniel Weathington, James Londino.Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity.Nat Commun. 2017 May 11;8:15203.