TargetMol

PfDHODH-IN-2

Product Code:
 
TAR-T8767
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8767-1mg1mg£124.00
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TAR-T8767-5mg5mg£201.00
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TAR-T8767-1mL1 mL * 10 mM (in DMSO)£213.00
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TAR-T8767-10mg10mg£269.00
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TAR-T8767-25mg25mg£436.00
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TAR-T8767-50mg50mg£610.00
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TAR-T8767-100mg100mg£838.00
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Further Information

Bioactivity:
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of malaria
CAS:
425629-94-3
Formula:
C13H12ClNO3S
Molecular Weight:
297.75
Pathway:
Metabolism; Microbiology/Virology
Purity:
0.9937
SMILES:
CCOC(=O)C1=C(Nc2ccc(Cl)cc2)SCC1=O
Target:
Dehydrogenase; Parasite

References

Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24.