TargetMol

CALP2 acetate(261969-04-4 free base)

Product Code:
 
TAR-TP1909L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-TP1909L1-1mg1mg£142.00
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TAR-TP1909L1-5mg5mg£219.00
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TAR-TP1909L1-10mg10mg£320.00
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TAR-TP1909L1-25mg25mg£519.00
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TAR-TP1909L1-50mg50mg£702.00
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TAR-TP1909L1-100mg100mg£970.00
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  • Further Information
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Further Information

Bioactivity:
CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 ?M. CALP2 acetate potently inhibits of adhesion and degranulation. CALP2 acetate is also a strong activator of alveolar macrophages. CALP2 acetate inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations.
CAS:
TP1909L1
Formula:
C68H104N14O13S
Molecular Weight:
1357.7
Pathway:
Neuroscience; Metabolism
Purity:
0.98
SMILES:
CC(C)[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](Cc1ccccc1)C(NCC(N[C@@H](C(C)C)C(NCC(N[C@@H](Cc1ccccc1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](Cc1ccccc1)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N
Target:
CaMK; PDE

Documents

References

Robert Ten Broeke, et al. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab Invest. 2004 Jan;84(1):29-40. M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85. R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3.