TargetMol

Linaclotide

Product Code:
 
TAR-T11852
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11852-1mg1mg£119.00
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TAR-T11852-2mg2mg£139.00
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TAR-T11852-5mg5mg£173.00
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TAR-T11852-10mg10mg£229.00
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TAR-T11852-1mL1 mL * 10 mM (in DMSO)£298.00
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TAR-T11852-25mg25mg£349.00
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TAR-T11852-50mg50mg£485.00
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TAR-T11852-100mg100mg£662.00
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This product comes from: United States.
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Further Information

Bioactivity:
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
CAS:
851199-59-2
Formula:
C59H79N15O21S6
Molecular Weight:
1526.73
Pathway:
GPCR/G Protein
Purity:
0.9871
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@]1([H])CSSC[C@H](N)C(=O)N[C@@]3([H])CSSC[C@]([H])(NC(=O)[C@H](C)NC2=O)C(=O)NC([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CSSC[C@]([H])(NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCC(O)=O)NC3=O)C(=O)N1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Target:
Guanylate cyclase

References

1. Bryant AP, et al. Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci. 2010 May 8;86(19-20):760-5. 2. Love BL, et al. Linaclotide: a novel agent for chronic constipation and irritable bowel syndrome. Am J Health Syst Pharm. 2014 Jul 1;71(13):1081-91.