TargetMol

GW843682X

Product Code:
 
TAR-T15454
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15454-1mg1mg£96.00
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TAR-T15454-2mg2mg£107.00
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TAR-T15454-5mg5mg£130.00
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TAR-T15454-1mL1 mL * 10 mM (in DMSO)£136.00
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TAR-T15454-10mg10mg£174.00
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TAR-T15454-25mg25mg£279.00
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TAR-T15454-50mg50mg£466.00
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TAR-T15454-100mg100mg£599.00
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Further Information

Bioactivity:
GW843682X is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
CAS:
660868-91-7
Formula:
C22H18F3N3O4S
Molecular Weight:
477.46
Pathway:
Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; Angiogenesis; Cell Cycle/Checkpoint
Purity:
0.9956
SMILES:
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC
Target:
VEGFR; PLK; CDK; PDGFR; Aurora Kinase

References

1. Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia. Eur J Pharmacol. 2008 Sep 4;591(1-3):102-5. 2. Ikezoe T, et al. A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies. Leukemia. 2009 Sep;23(9):1564-76. 3. Lansing TJ, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31.