TargetMol

AZD4547

Product Code:
 
TAR-T1948
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1948-2mg2mg£97.00
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TAR-T1948-5mg5mg£107.00
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TAR-T1948-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T1948-10mg10mg£116.00
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TAR-T1948-25mg25mg£136.00
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TAR-T1948-50mg50mg£163.00
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TAR-T1948-100mg100mg£197.00
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TAR-T1948-200mg200mg£255.00
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TAR-T1948-500mg500mg£381.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays).
CAS:
1035270-39-3
Formula:
C26H33N5O3
Molecular Weight:
463.582
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9974
SMILES:
COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
Target:
VEGFR; FGFR

Documents

References

1. Gavine PR, et al. AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res, 2012, 72(8), 2045-2056. 2. Zhang J, et al. Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of patient-derived tumor xenograft models. Clin Cancer Res. 2012 Dec 15;18(24):6658-67. 3. Pu X, Ye Q, Cai J, et al. Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas[J]. Cell death & disease. 2021, 12(3): 1-14.