TargetMol

(R)-(-)-JQ1 Enantiomer

Product Code:
 
TAR-T19618
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19618-1mg1mg£105.00
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TAR-T19618-2mg2mg£119.00
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TAR-T19618-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T19618-5mg5mg£164.00
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TAR-T19618-10mg10mg£229.00
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TAR-T19618-25mg25mg£389.00
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TAR-T19618-50mg50mg£568.00
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TAR-T19618-100mg100mg£777.00
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Further Information

Bioactivity:
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
CAS:
1268524-71-5
Formula:
C23H25ClN4O2S
Molecular Weight:
456.99
Pathway:
Chromatin/Epigenetic
Purity:
0.9803
SMILES:
Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Target:
Epigenetic Reader Domain

References

1. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Apr;10(4). pii: e8163. 2. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.