TargetMol

PH-797804

Product Code:
 
TAR-T1974
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1974-1mg1mg£103.00
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TAR-T1974-2mg2mg£115.00
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TAR-T1974-5mg5mg£148.00
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TAR-T1974-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T1974-10mg10mg£198.00
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TAR-T1974-25mg25mg£341.00
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TAR-T1974-50mg50mg£507.00
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TAR-T1974-100mg100mg£701.00
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TAR-T1974-200mg200mg£938.00
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TAR-T1974-500mg500mg£1,380.00
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Further Information

Bioactivity:
PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.
CAS:
586379-66-0
Formula:
C22H19BrF2N2O3
Molecular Weight:
477.306
Pathway:
MAPK; Autophagy
Purity:
0.9896
SMILES:
CNC(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O
Target:
p38 MAPK; Autophagy

References

1. Hope HR, et al, J Pharmacol Exp Ther, 2009, 331(3), 882-895. 2. Xing L, et al. Biochemistry, 2009, 48(27), 6402-6411.