MCC950
Product Code:
TAR-T3701
TAR-T3701
Regulatory Status:
RUO
RUO
Shipping:
cool pack
cool pack
Storage:
-20℃
-20℃
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| TAR-T3701-2mg | 2mg | £104.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3701-5mg | 5mg | £113.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3701-1mL | 1 mL * 10 mM (in DMSO) | £116.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3701-10mg | 10mg | £142.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3701-25mg | 25mg | £223.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3701-50mg | 50mg | £347.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3701-100mg | 100mg | £562.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
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Further Information
Bioactivity:
CP-456773 (MCC950 and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced IL-1β production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis.
CAS:
210826-40-7
Formula:
C20H24N2O5S
Molecular Weight:
404.48
Pathway:
NF-κb; Immunology/Inflammation
Purity:
0.98
SMILES:
CC(C)(O)c1coc(c1)S(=O)(=O)NC(=O)Nc1c2CCCc2cc2CCCc12
Target:
NOD
References
Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2021 Feb 11;19(1):13. doi: 10.1186/s12964-020-00647-1.
Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li et al. Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome [J]. Acta Pharmaceutica Sinica B. 2019 Feb 14.
Cao X, Di G, Bai Y, et al.Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands.Investigative Ophthalmology & Visual Science.2023, 64(1): 4-4.
Yang S R, Hua K F, Yang C Y, et al. Cf?02, a novel benzamide?linked small molecule, blunts NF??B activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe lupus nephritis in mice. The FASEB Journal. 2021, 35(8): e21785.
Li S, Hui Y, Yuan J, et al. Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma?COPD Overlap in vivo and in vitro[J]. Journal of Inflammation Research. 2021, 14: 2173-2185.
Li Q, Zhao P, Wen Y, et al.POLYDATIN AMELIORATES TRAUMATIC BRAIN INJURY?INDUCED SECONDARY BRAIN INJURY BY INHIBITING NLRP3-INDUCED NEUROINFLAMMATION ASSOCIATED WITH SOD2 ACETYLATION.Shock.2023, 59(3): 460-468.
Niu L, Luo S S, Xu Y, et al. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice. Neurobiology of Learning and Memory. 2020: 107301
Chen Y Q, Wang S N, Shi Y J, et al. CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment[J]. Journal of Neuroinflammation. 2020, 17(1): 1-18.
Tian C, Han X, He L, et al. Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. Molecular and Cellular Biochemistry. 2020: 1-14
Ni B, Pei W, Qu Y, et al. MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis. Oxidative Medicine and Cellular Longevity. 2021, 2021.
Tian C, Huang R, Tang F, et al. Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation. The Journal of Membrane Biology. 2019: 1-13
Wang Z, Xu G, Gao Y, et al. Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome. Acta Pharmaceutica Sinica B. 2019, 9(4): 734-744
Xie D, Ge X, Ma Y, et al. Clemastine improves hypomyelination in rats with hypoxic?ischemic brain injury by reducing microglia-derived IL-1? via P38 signaling pathway. Journal of neuroinflammation. 2020, 17(1): 1-17.
Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55.
Wei Shi, Guang Xu, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Nan Qin, Xiaorong Hou, Yongqiang Ai, Chunyu Wang, Tingting He, Hongbin Liu, Yuanyuan Chen, Yan Liu, Jiabo Wang, Ming Niu, Yuming Guo, Xiaohe Xiao & Zhaofang Bai. Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases. Cell death & disease. 2020
Li S, Hui Y, Yuan J, et al. Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma?COPD Overlap in vivo and in vitro. Journal of Inflammation Research. 2021, 14: 2173-2185.
Wu C H, Gan C H, Li L H, et al. A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction. Frontiers in Immunology. 2020 Dec 18;11:607564. doi: 10.3389/fimmu.2020.607564. eCollection 2020.
Li N, Jiang X, Zhang R, et al.Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis.Journal of Medicinal Chemistry.2023
Chen Y Q, Wang S N, Shi Y J, et al. CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment. Journal of Neuroinflammation. 2020, 17(1): 1-18.
Wei Shi, Guang Xu, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Nan Qin, Xiaorong Hou, Yongqiang Ai, Chunyu Wang, Tingting He, Hongbin Liu, Yuanyuan Chen, Yan Liu, Jiabo Wang, Ming Niu, Yuming Guo, Xiaohe Xiao & Zhaofang Bai Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases. Cell Death & Disease. 2020
Li L H, Lin J S, Chiu H W, et al. Mechanistic insight into the activation of the NLRP3 inflammasome by Neisseria gonorrhoeae in macrophages[J]. Frontiers in Immunology. 2019, 10: 1815.
Zhang H, Gao J, Fang W, et al. Role of NINJ1 in Gout Flare and Potential as a Drug Target. Journal of Inflammation Research. 2022, 15: 5611-5620.
Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2020
Meng Z, Liu H, Zhang J, et al. Sesamin promotes apoptosis and pyroptosis via autophagy to enhance antitumour effects on murine T-cell lymphoma. Journal of Pharmacological Sciences. 2021
Li L H, Lin J S, Chiu H W, et al. Mechanistic insight into the activation of the NLRP3 inflammasome by Neisseria gonorrhoeae in macrophages. Frontiers in Immunology. 2019, 10: 1815
Shi W, Xu G, Gao Y, et al.Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase.Journal of Translational Medicine.2023, 21(1): 1-17.
Qin N, Xu G, Wang Y, et al. Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity. Frontiers of Medicine. 2021 Aug;15(4):594-607.
Wu C H, Gan C H, Li L H, et al. A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction[J]. Frontiers in Immunology. 2020, 11.
Li L H, Chen T L, Chiu H W, et al. Critical Role for the NLRP3 Inflammasome in Mediating IL-1? Production in Shigella sonnei-Infected Macrophages[J]. Frontiers in Immunology. 2020, 11: 1115.
Li L H, Chen T L, Chiu H W, et al. Critical Role for the NLRP3 Inflammasome in Mediating IL-1? Production in Shigella sonnei-Infected Macrophages. Frontiers in Immunology. 2020, 11: 1115
Xie D, Ge X, Ma Y, et al. Clemastine improves hypomyelination in rats with hypoxic?ischemic brain injury by reducing microglia-derived IL-1? via P38 signaling pathway[J]. Journal of Neuroinflammation. 2020, 17(1): 1-17.