TargetMol

BGG463

Product Code:
 
TAR-T4618
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4618-1mg1mg£115.00
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TAR-T4618-2mg2mg£134.00
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TAR-T4618-5mg5mg£168.00
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TAR-T4618-1mL1 mL * 10 mM (in DMSO)£196.00
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TAR-T4618-10mg10mg£230.00
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TAR-T4618-25mg25mg£367.00
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TAR-T4618-50mg50mg£497.00
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TAR-T4618-100mg100mg£687.00
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Further Information

Bioactivity:
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively.
CAS:
890129-26-7
Formula:
C30H29F3N6O3
Molecular Weight:
578.596
Pathway:
Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint; Angiogenesis; Cytoskeletal Signaling
Purity:
1
SMILES:
CN1CCN(Cc2ccc(NC(=O)c3cccc4cc(Oc5cc(NC(C)=O)ncn5)ccc34)cc2C(F)(F)F)CC1
Target:
Bcr-Abl; CDK

References

Jiang L, Yu Y, Li Z, et al.BMS-265246, a Cyclin-Dependent Kinase Inhibitor, Inhibits the Infection of Herpes Simplex Virus Type 1.Viruses.2023, 15(8): 1642. Alexander LT, et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25.