TargetMol

Dovitinib Dilactic Acid

Product Code:
 
TAR-T6193
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T6193-1mL1 mL * 10 mM (in DMSO)Enquire
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TAR-T6193-100mg100mgEnquire
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TAR-T6193-10mg10mgEnquire
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TAR-T6193-25mg25mgEnquire
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TAR-T6193-50mg50mgEnquire
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TAR-T6193-5mg5mgEnquire
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Further Information

Bioactivity:
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
CAS:
852433-84-2
Formula:
C27H33FN6O7
Molecular Weight:
572.594
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CC(O)C(O)=O.CC(O)C(O)=O.CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Target:
VEGFR; FGFR; FLT; c-Kit

Documents

References

Trudel S, et al. Blood, 2005, 105(7), 2941-2948. Lee SH, et al. Clin Cancer Res. 2005, 11(10), 3633-3641. Azab AK, et al. Clin Cancer Res, 2011, 17(13), 4389-4399. Huynh H, et al. J Hepatol. 2012, 56(3), 595-601.