TargetMol

Givinostat hydrochloride

Product Code:
 
TAR-T6279L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6279L-1mg1mg£124.00
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TAR-T6279L-2mg2mg£147.00
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TAR-T6279L-5mg5mg£180.00
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TAR-T6279L-1mL1 mL * 10 mM (in DMSO)£246.00
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TAR-T6279L-10mg10mg£253.00
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TAR-T6279L-25mg25mg£454.00
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TAR-T6279L-50mg50mg£631.00
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TAR-T6279L-100mg100mg£868.00
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TAR-T6279L-500mg500mg£1,669.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Givinostat hydrochloride is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities.
CAS:
199657-29-9
Formula:
C24H28ClN3O4
Molecular Weight:
457.96
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.98
SMILES:
Cl.CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1
Target:
HDAC

Documents

References

Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15. Zappasodi R, et al. Pleiotropic antitumor effects of the pan-HDAC inhibitor ITF2357 against c-Myc-overexpressing human B-cell non-Hodgkin lymphomas. Int J Cancer. 2014 Nov 1;135(9):2034-45. Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39. Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.