TargetMol

HALOFUGINONE LACTATE

Product Code:
 
TAR-T8785
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8785-1mg1mg£115.00
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TAR-T8785-2mg2mg£133.00
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TAR-T8785-5mg5mg£163.00
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TAR-T8785-1mL1 mL * 10 mM (in DMSO)£196.00
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TAR-T8785-10mg10mg£213.00
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TAR-T8785-25mg25mg£287.00
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TAR-T8785-50mg50mg£430.00
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TAR-T8785-100mg100mg£600.00
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TAR-T8785-500mg500mg£1,179.00
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  • Further Information
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Further Information

Bioactivity:
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity
CAS:
82186-71-8
Formula:
C19H23BrClN3O6
Molecular Weight:
504.76
Pathway:
Stem Cells; DNA Damage/DNA Repair; Cell Cycle/Checkpoint
Purity:
0.9982
SMILES:
CC(O)C(O)=O.O[C@@H]1CCCN[C@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Target:
DNA/RNA Synthesis; TGF-beta/Smad

Documents

References

Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. Bin, Guo-Hua, Xian-Feng, et al. Halofuginone protects HUVECs from H2O2-induced injury by modulating VEGF/JNK signaling pathway.[J]. Journal of the Chinese Medical Association : JCMA, 2019. Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247. Cui Z, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-? activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21.