TargetMol

CL 316243

Product Code:
 
TAR-T10830
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10830-1mg1mg£109.00
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TAR-T10830-5mg5mg£161.00
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TAR-T10830-10mg10mg£209.00
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TAR-T10830-25mg25mg£349.00
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TAR-T10830-50mg50mg£516.00
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Quantity:
TAR-T10830-100mg100mg£784.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.
CAS:
138908-40-4
Formula:
C20H18ClNNa2O7
Molecular Weight:
465.79
Pathway:
GPCR/G Protein; Neuroscience
Purity:
0.98
SMILES:
[Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c1cccc(Cl)c1
Target:
Adrenergic Receptor

Documents

References

1. Bloom JD, et al. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.J Med Chem. 1992 Aug 7;35(16):3081-4. 2. Shin W, et al. Impaired adrenergic agonist-dependent beige adipocyte induction in obese mice.J Vet Med Sci. 2019 Jun 6;81(6):799-807.