TargetMol

AMG-076

Product Code:
 
TAR-T23719
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
AMG-076 is an antagonist of melanin-concentrating hormone receptor 1. It also reduced hERG inhibition.
CAS:
1001438-96-5
Formula:
C32H39F3N2O5S
Molecular Weight:
620.73
Purity:
0.98
SMILES:
OS(=O)(=O)c1ccccc1.[H][C@]12CCN(CCC3(CCCCC3)C(O)=O)C[C@]1([H])[C@@H](C)c1c(C2)[nH]c2ccc(cc12)C(F)(F)F

Documents

References

1. Motani AS, Luo J, Liang L, Mihalic JT, Chen X, Tang L, Li L, Jaen J, Chen JL, Dai K. Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models. Pharmacol Res Perspect. 2013 Oct;1(1):e00003. doi: 10.1002/prp2.3. Epub 2013 Sep 17. PubMed PMID: 25505557; PubMed Central PMCID: PMC4184568. 2. Mihalic JT, Fan P, Chen X, Chen X, Fu Y, Motani A, Liang L, Lindstrom M, Tang L, Chen JL, Jaen J, Dai K, Li L. Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3781-5. doi: 10.1016/j.bmcl.2012.04.006. Epub 2012 Apr 7. PubMed PMID: 22542010. 3. Andersen D, Storz T, Liu P, Wang X, Li L, Fan P, Chen X, Allgeier A, Burgos A, Tedrow J, Baum J, Chen Y, Crockett R, Huang L, Syed R, Larsen RD, Martinelli M. Stereoselective synthesis of a MCHr1 antagonist. J Org Chem. 2007 Dec 7;72(25):9648-55. Epub 2007 Nov 13. PubMed PMID: 17997573.