L 645151
Code | Size | Price |
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TAR-T24300-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24300-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24300-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
L 645151 is an inhibitor of lipophilic CA.
CAS:
86394-94-7
Formula:
C12H14N2O4S2
Molecular Weight:
314.37
Purity:
0.98
SMILES:
CC(C)(C)C(=O)Oc1ccc2nc(sc2c1)S(N)(=O)=O
References
1. Wetzel P, Kleinke T, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase slows the Ca(2+) transient in rat skeletal muscle fibers. Am J Physiol Cell Physiol. 2002 Oct;283(4):C1242-53. PubMed PMID: 12225987.
2. Wetzel P, Papadopoulos S, Gros G. Inhibition of muscle carbonic anhydrase increases rise and relaxation times of twitches in rat skeletal muscle fibres. Pflugers Arch. 2002 Mar;443(5-6):762-70. Epub 2002 Jan 22. PubMed PMID: 11889574.
3. Woltersdorf OW Jr, Schwam H, Bicking JB, Brown SL, deSolms SJ, Fishman DR, Graham SL, Gautheron PD, Hoffman JM, Larson RD, et al. Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide. J Med Chem. 1989 Nov;32(11):2486-92. PubMed PMID: 2810337.
4. Bar-Ilan A, Pessah NI, Maren TH. Ocular penetration and hypotensive activity of the topically applied carbonic anhydrase inhibitor L-645,151. J Ocul Pharmacol. 1986 Spring;2(2):109-20. PubMed PMID: 3503100.