TargetMol

YM928

Product Code:
 
TAR-T24663
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24663-5mg5mg£850.00
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TAR-T24663-50mg50mg£1,661.00
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Quantity:
TAR-T24663-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
YM928 is an orally active antagonist of the AMPA receptor.
CAS:
190842-36-5
Formula:
C14H10ClN3OS
Molecular Weight:
303.76
Purity:
0.98
SMILES:
CN(c1ccc(Cl)cc1)c1nc(=O)c2cccnc2s1

References

1. Inami H, Shishikura J, Yasunaga T, Ohno K, Yamashita H, Kato K, Sakamoto S. Synthesis, structure-activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists. Bioorg Med Chem. 2015 Apr 15;23(8):1788-99. doi: 10.1016/j.bmc.2015.02.033. Epub 2015 Feb 25. PubMed PMID: 25792143. 2. Kato K, Noguchi K, Aoki T, Soeishi Y, Kamimura H. Simultaneous determination of YM928, a novel noncompetitive AMPA receptor antagonist, and its demethylated metabolite in rat, dog and monkey plasma by high-performance liquid chromatography with ultraviolet detection. Biomed Chromatogr. 2006 Dec;20(12):1328-35. PubMed PMID: 16977590. 3. Yamashita H, Ohno K, Amada Y, Inami H, Shishikura J, Sakamoto S, Okada M, Yamaguchi T. Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):99-105. Epub 2004 Jul 31. PubMed PMID: 15322731. 4. Yamashita H, Ohno K, Inami H, Shishikura J, Sakamoto S, Okada M, Yamaguchi T. Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy. Eur J Pharmacol. 2004 Jun 28;494(2-3):147-54. PubMed PMID: 15212968.