TargetMol

TROX-1

Product Code:
 
TAR-T24902
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24902-5mg5mg£1,010.00
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TAR-T24902-50mg50mg£1,982.00
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Quantity:
TAR-T24902-100mg100mg£2,560.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
TROX-1 is the activation state-dependent Cav2 channel antagonist.
CAS:
1309601-26-0
Formula:
C22H16ClFN6O
Molecular Weight:
434.86
Purity:
0.98
SMILES:
C[C@]1(Cc2cncnc2)C(=O)N(c2nc[nH]n2)c2ccc(cc12)-c1ccc(F)c(Cl)c1

References

1. Rahman W, Patel R, Dickenson AH. Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis. Neuroscience. 2015 Oct 1;305:76-85. doi: 10.1016/j.neuroscience.2015.07.073. Epub 2015 Aug 4. PubMed PMID: 26247695; PubMed Central PMCID: PMC4564012. 2. Patel R, Rutten K, Valdor M, Schiene K, Wigge S, Schunk S, Damann N, Christoph T, Dickenson AH. Electrophysiological characterization of activation state-dependent Ca(v)2 channel antagonist TROX-1 in spinal nerve injured rats. Neuroscience. 2015 Jun 25;297:47-57. doi: 10.1016/j.neuroscience.2015.03.057. Epub 2015 Apr 1. PubMed PMID: 25839150; PubMed Central PMCID: PMC4436437. 3. Swensen AM, Herrington J, Bugianesi RM, Dai G, Haedo RJ, Ratliff KS, Smith MM, Warren VA, Arneric SP, Eduljee C, Parker D, Snutch TP, Hoyt SB, London C, Duffy JL, Kaczorowski GJ, McManus OB. Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels. Mol Pharmacol. 2012 Mar;81(3):488-97. doi: 10.1124/mol.111.075226. Epub 2011 Dec 21. PubMed PMID: 22188924. 4. Abbadie C, McManus OB, Sun SY, Bugianesi RM, Dai G, Haedo RJ, Herrington JB, Kaczorowski GJ, Smith MM, Swensen AM, Warren VA, Williams B, Arneric SP, Eduljee C, Snutch TP, Tringham EW, Jochnowitz N, Liang A, Euan MacIntyre D, McGowan E, Mistry S, White VV, Hoyt SB, London C, Lyons KA, Bunting PB, Volksdorf S, Duffy JL. Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55. doi: 10.1124/jpet.110.166363. Epub 2010 May 3. PubMed PMID: 20439438.