TargetMol

Albocycline

Product Code:
 
TAR-T25027
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T25027-25mg25mgEnquire
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  • Further Information
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Further Information

Bioactivity:
Albocycline is a Macrolide antibiotic from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains.
CAS:
25129-91-3
Formula:
C18H28O4
Molecular Weight:
308.418
Purity:
0.98
SMILES:
CO[C@H]1C=C/[C@@](C)(O)C=C/C(=O)O[C@H](C)[C@@H](C)CCC=C1C

Documents

References

1. Liang H, Zhou G, Ge Y, D'Ambrosio EA, Eidem TM, Blanchard C, Shehatou C, Chatare VK, Dunman PM, Valentine AM, Voelz VA, Grimes CL, Andrade RB. Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus. Bioorg Med Chem. 2018 Jul 23;26(12):3453-3460. doi: 10.1016/j.bmc.2018.05.017. Epub 2018 May 24. PubMed PMID: 29805074; PubMed Central PMCID: PMC6008248. 2. Managamuri U, Vijayalakshmi M, Ganduri VSRK, Rajulapati SB, Bonigala B, Kalyani BS, Poda S. Isolation, identification, optimization, and metabolite profiling of Streptomyces sparsus VSM-30. 3 Biotech. 2017 Jul;7(3):217. doi: 10.1007/s13205-017-0835-1. Epub 2017 Jul 1. PubMed PMID: 28669076; PubMed Central PMCID: PMC5494031. 3. Chatare VK, Andrade RB. Total Synthesis of (-)-Albocycline. Angew Chem Int Ed Engl. 2017 May 15;56(21):5909-5911. doi: 10.1002/anie.201702530. Epub 2017 Apr 21. PubMed PMID: 28429505. 4. O'Brien RV, Davis RW, Khosla C, Hillenmeyer ME. Computational identification and analysis of orphan assembly-line polyketide synthases. J Antibiot (Tokyo). 2014 Jan;67(1):89-97. doi: 10.1038/ja.2013.125. Epub 2013 Dec 4. PubMed PMID: 24301183; PubMed Central PMCID: PMC4028714.