TargetMol

Aminopterin N-hydroxysuccinimide ester

Product Code:
 
TAR-T25079
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis.
CAS:
98457-88-6
Formula:
C23H25N9O7
Molecular Weight:
539.509
Purity:
0.98
SMILES:
O=C1CCC(=O)[NH2+]1.CN(c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O)c1cnc2nc(N)nc(N)c2n1

Documents

References

1. Chiao JH, Roy K, Tolner B, Yang CH, Sirotnak FM. RFC-1 gene expression regulates folate absorption in mouse small intestine. J Biol Chem. 1997 Apr 25;272(17):11165-70. PubMed PMID: 9111015. 2. Yang CH, Sirotnak FM, Mines LS. Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization following affinity labeling. J Biol Chem. 1988 Jul 15;263(20):9703-9. PubMed PMID: 2838477.