TargetMol

EP6

Product Code:
 
TAR-T25377
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25377-5mg5mg£850.00
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Quantity:
TAR-T25377-50mg50mg£1,661.00
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Quantity:
TAR-T25377-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
EP6 is an inhibitor of 5-lipoxygenase (5-LO), which is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and allergic reactions.
CAS:
1353567-32-4
Formula:
C24H30N4O
Molecular Weight:
390.531
Purity:
0.98
SMILES:
Cc1ccc2nc(c(NC3CCCCC3)n2c1)-c1ccc(cc1)N1CCOCC1

References

1. Wisniewska JM, R?dl CB, Kahnt AS, Buscat? El, Ulrich S, Tanrikulu Y, Achenbach J, R?rsch F, Gr?sch S, Schneider G, Cinatl J Jr, Proschak E, Steinhilber D, Hofmann B. Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochem Pharmacol. 2012 Jan 15;83(2):228-40. doi: 10.1016/j.bcp.2011.10.012. Epub 2011 Oct 18. PubMed PMID: 22027220. 2. Pires ES, Choudhury AK, Idicula-Thomas S, Khole VV. Anti-HSP90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP6 (380-389) of HSP90 beta protein. Reprod Biol Endocrinol. 2011 Jan 27;9:16. doi: 10.1186/1477-7827-9-16. PubMed PMID: 21272367; PubMed Central PMCID: PMC3039567. 3. Smith MC, Sephel GC, Woodward SC. Spreadsheet templates for calculating linearity according to EP6-P. MLO Med Lab Obs. 1992 Nov;24(11):59-60, 62. PubMed PMID: 10122447. 4. Leontiou CA, Hadjidaniel MD, Mina P, Antoniou P, Ioannides M, Patsalis PC. Bisulfite Conversion of DNA: Performance Comparison of Different Kits and Methylation Quantitation of Epigenetic Biomarkers that Have the Potential to Be Used in Non-Invasive Prenatal Testing. PLoS One. 2015 Aug 6;10(8):e0135058. doi: 10.1371/journal.pone.0135058. eCollection 2015. PubMed PMID: 26247357; PubMed Central PMCID: PMC4527772.