TargetMol

Epiroprim

Product Code:
 
TAR-T25381
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25381-5mg5mg£850.00
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TAR-T25381-50mg50mg£1,661.00
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Quantity:
TAR-T25381-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Epiroprim is an analog of trimethoprim and a dihydrofolate reductase inhibitor.
CAS:
73090-70-7
Formula:
C19H23N5O2
Molecular Weight:
353.426
Purity:
0.98
SMILES:
CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-n1cccc1

References

1. Martinez A, Allegra CJ, Kovacs JA. Efficacy of epiroprim (Ro11-8958), a new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice. Am J Trop Med Hyg. 1996 Mar;54(3):249-52. PubMed PMID: 8600759. 2. Dhople AM. In vitro activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with brodimoprim and dapsone, against Mycobacterium leprae. Int J Antimicrob Agents. 1999 Aug;12(4):319-23. PubMed PMID: 10493608. 3. Chang HR, Arsenijevic D, Comte R, Polak A, Then RL, Pech?re JC. Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii. Antimicrob Agents Chemother. 1994 Aug;38(8):1803-7. PubMed PMID: 7986011; PubMed Central PMCID: PMC284639. 4. Luttringer O, Theil FP, Poulin P, Schmitt-Hoffmann AH, Guentert TW, Lav? T. Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans. J Pharm Sci. 2003 Oct;92(10):1990-2007. PubMed PMID: 14502539.