TargetMol

Lubeluzole

Product Code:
 
TAR-T25761
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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  • Further Information
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Further Information

Bioactivity:
Lubeluzole, a well-known neuroprotective agent, is recently proved useful to potentiate the activity of anti-cancer drugs.
CAS:
144665-07-6
Formula:
C22H25F2N3O2S
Molecular Weight:
433.52
Purity:
0.98
SMILES:
CN(C1CCN(C[C@H](O)COc2ccc(F)c(F)c2)CC1)c1nc2ccccc2s1

Documents

References

1. Desaphy JF, Carbonara R, Costanza T, Lentini G, Cavalluzzi MM, Bruno C, Franchini C, Camerino DC. Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials. Mol Pharmacol. 2013 Feb;83(2):406-15. doi: 10.1124/mol.112.080804. Epub 2012 Nov 21. PubMed PMID: 23175529. 2. Bruno C, Cavalluzzi MM, Rusciano MR, Lovece A, Carrieri A, Pracella R, Giannuzzi G, Polimeno L, Viale M, Illario M, Franchini C, Lentini G. The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II. Eur J Med Chem. 2016 Jun 30;116:36-45. doi: 10.1016/j.ejmech.2016.03.045. Epub 2016 Mar 19. PubMed PMID: 27043269. 3. Kommi DN, Kumar D, Seth K, Chakraborti AK. Protecting group-free concise synthesis of (RS)/(S)-lubeluzole. Org Lett. 2013 Mar 15;15(6):1158-61. doi: 10.1021/ol302601b. Epub 2013 Feb 22. PubMed PMID: 23432765. 4. Cavalluzzi MM, Viale M, Bruno C, Carocci A, Catalano A, Carrieri A, Franchini C, Lentini G. A convenient synthesis of lubeluzole and its enantiomer: evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4820-3. doi: 10.1016/j.bmcl.2013.06.077. Epub 2013 Jul 4. PubMed PMID: 23886686.